Abstract: The Cambrian explosion of AI powered tools has raised important questions about their use in education. The TPACK framework address the knowledge and skills that educators need to effectively integrate such emergent technologies into their current and future learning environments. As technologies continue to rapidly evolve, TPACK must likewise adapt to new eco-technological changes. The recent emergence of freely available AI tools such as OpenAI’s ChatGPT have the potential to revolutionize education. In this brief paper we examine the use of AI powered tools using neural network-based models in education and how the TPACK framework can be applied to consider the implications of these technologies on teaching and learning. We also explore the opportunities for educators to create new, authentic, and deeper learning experiences in their learning environments using AI tools, while also considering the potential risks and challenges.