Abstract: The BioSense Network is a collaboration between Arizona State University’s Biodesign Institute and the Mary Lou Fulton Teachers College, supported by grant funding from the U.S. Department of Defense National Defense Education Program. The purpose of this network is to build a community of educators who can inspire and educate middle and high school students in sense-making around biotechnology concepts and applications. In this brief paper, we will share the foundations, ongoing developments, and pedagogical approaches to a project in-process with a bold ambition to create no-cost biotechnology curriculum. This paper outlines the main elements of this project including the module development, teacher training, and the technical aspects of creating a computational microscope platform to bring high powered cloud computing virtualizations of the ‘invisible’ molecular world to inspire students interest in a potential STEM professional pathway.